GCL is composed of a heavy catalytic subunit (GCLC, MW ~ 73,000) and a light modifier (GCLM, MW ~ 30,000) subunit
If side effects are severe at a given dose, you have options
Sublingual troches: Typical dose: 50-200mcg per troche Frequency: 1-2 times daily Administration: Dissolve between cheek and gum for 15-20 minutes Absorption: Bypasses first-pass liver metabolism through oral mucosa Liposomal oral: Typical dose: 100-500mcg Frequency: Once daily Note: Lipid encapsulation protects peptide through digestion Oral forms suit those unwilling to inject who still want systemic rather than purely local effects
Ligament and Tendon Injuries The spinal ligaments (including the interspinous, supraspinous, and longitudinal ligaments) can become strained or partially torn
Direct Adrenergic Agonism: Ephedrine is also able to directly bind to multiple post-synaptic adrenergic receptor subtypes to initiate intracellular signaling cascades: : Activation of vascular smooth muscle 1 -Adrenergic Activation 1 -adrenergic receptors produces arterial and venous vasoconstriction, leading to an increase in systemic vascular resistance (SVR), diastolic blood pressure, and systolic blood pressure (Solanki et al, 2014)
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